I’m just now listening to it, and I still need to finish the last 15 minutes, but I’ll recommend episode 3 of Hypercritical, John Siracusa’s podcast with Dan Benjamin.
In the first half* of the podcast, John explains the vision behind the major UI changes planned for Mac OS X Lion, and really sold me on the vision. Then in the second half, he explains that about half of it won’t work, and he’s probably right.
* The first portion is actually spillover discussion on backups from episode 2. So it’s the first half of the main part of the episode. That’s also a good episode. Are you doing your backups properly?